LSD (Lysergic Acid Diethylamide)
Definition
A potent synthetic hallucinogen derived from lysergic acid, itself from ergot alkaloids of Claviceps purpurea. Active at 50-200 μg. Schedule I in the US, Class A in the UK. Detected by HPLC-FLD (fluorescence Ex 325/Em 445 nm) or LC-MS/MS ([M+H]+ m/z 324).
Related terms
- 1P-LSD (1-Propionyl-LSD)
- A lysergamide prodrug bearing a propionyl group on the indole N1 position; cleaved in vivo to release LSD. Sold legally in some...
- 5-MeO-DMT
- 5-Methoxy-N,N-dimethyltryptamine; present in Bufo alvarius toad venom at ~15% by weight. Active dose 1-5 mg by inhalation. Schedule I in US since...
- Ayahuasca
- A traditional Amazonian brew combining a DMT-containing plant (Psychotria viridis) with Banisteriopsis caapi containing beta-carboline MAO inhibitors (harmine, harmaline), allowing oral bioavailability...
- Beta-Carboline Alkaloids
- Harmine, harmaline, and tetrahydroharmine; reversible MAO-A inhibitors from Banisteriopsis caapi vine that form the MAOI component of ayahuasca. Detected by HPLC-UV at...
- Breakthrough Therapy Designation (FDA)
- An FDA designation that expedites review of drugs showing preliminary clinical evidence of substantial improvement over available therapy for serious conditions. Awarded...
- DMT (N,N-Dimethyltryptamine)
- The simplest tryptamine hallucinogen, MW 188.27 g/mol, orally inactive due to MAO metabolism; active when smoked (25-60 mg) or combined with MAO...
- Ehrlich Reagent
- A presumptive colour test for indole-containing compounds: p-dimethylaminobenzaldehyde in HCl/ethanol. Produces purple-violet with LSD, psilocybin, and all tryptamines. Not specific; many non-drug...
- Psilocin
- 4-Hydroxy-N,N-dimethyltryptamine; the active deacylated metabolite of psilocybin responsible for psychedelic effects. Rapidly oxidises in solution, causing the characteristic blue bruising in Psilocybe...
- Psilocybin
- 4-Phosphoryloxy-N,N-dimethyltryptamine; a prodrug found in Psilocybe genus mushrooms. Dephosphorylated in vivo to psilocin (the active form) by alkaline phosphatase. Active at 1-4...
Explained in
- Hallucinogens: LSD, Psilocybin, DMT and the Indolealkylamine FamilyA potent synthetic hallucinogen derived from lysergic acid, itself from ergot alkaloids of Claviceps purpurea. Active at 50-200 μg. Schedule I in the US, Class...