1P-LSD (1-Propionyl-LSD)
Definition
A lysergamide prodrug bearing a propionyl group on the indole N1 position; cleaved in vivo to release LSD. Sold legally in some EU markets until blanket scheduling (UK PSA 2016, German BtMG amendment 2019). Detected by LC-MS/MS [M+H]+ m/z 366.
- Structure
- Propionyl group on the indole N1 of LSD
- Mechanism
- Prodrug, cleaved in vivo to release LSD
- UK scheduling
- Banned under the Psychoactive Substances Act 2016
- Germany scheduling
- Banned under 2019 BtMG amendment
- LC-MS/MS marker
- [M+H]+ m/z 380
Common questions
Why was 1P-LSD sold legally in some markets before it was banned?+
As a structurally modified analogue not explicitly named in older drug schedules, it exploited a legal-high loophole in some countries until specific bans or broader analogue legislation caught up with it.
How can a lab tell 1P-LSD apart from LSD itself in a sample?+
The intact prodrug has its own mass and retention time, seen as [M+H]+ at m/z 380 on LC-MS/MS, distinct from LSD, so analysis of an unmetabolized sample can identify possession of the analogue rather than LSD.
Related terms
- 5-MeO-DMT
- 5-Methoxy-N,N-dimethyltryptamine; present in Bufo alvarius toad venom at ~15% by weight. Active dose 1-5 mg by inhalation. Schedule I in US since...
- Ayahuasca
- A traditional Amazonian brew combining a DMT-containing plant (Psychotria viridis) with Banisteriopsis caapi containing beta-carboline MAO inhibitors (harmine, harmaline), allowing oral bioavailability...
- Beta-Carboline Alkaloids
- Harmine, harmaline, and tetrahydroharmine; reversible MAO-A inhibitors from Banisteriopsis caapi vine that form the MAOI component of ayahuasca. Detected by HPLC-UV at...
- Breakthrough Therapy Designation (FDA)
- An FDA designation that expedites review of drugs showing preliminary clinical evidence of substantial improvement over available therapy for serious conditions. Awarded...
- DMT (N,N-Dimethyltryptamine)
- The simplest tryptamine hallucinogen, MW 188.27 g/mol, orally inactive due to MAO metabolism; active when smoked (25-60 mg) or combined with MAO...
- Ehrlich Reagent
- A presumptive colour test for indole-containing compounds: p-dimethylaminobenzaldehyde in HCl/ethanol. Produces purple-violet with LSD, psilocybin, and all tryptamines. Not specific; many non-drug...
- LSD (Lysergic Acid Diethylamide)
- A potent synthetic hallucinogen derived from lysergic acid, itself from ergot alkaloids of Claviceps purpurea. Active at 50-200 μg. Schedule I in...
- Psilocin
- 4-Hydroxy-N,N-dimethyltryptamine; the active deacylated metabolite of psilocybin responsible for psychedelic effects. Rapidly oxidises in solution, causing the characteristic blue bruising in Psilocybe...
- Psilocybin
- 4-Phosphoryloxy-N,N-dimethyltryptamine; a prodrug found in Psilocybe genus mushrooms. Dephosphorylated in vivo to psilocin (the active form) by alkaline phosphatase. Active at 1-4...