Dermcidin
Definition
An antimicrobial peptide secreted constitutively by eccrine sweat glands. The primary candidate marker for immunological identification of sweat in forensic samples, though validated forensic assays are not yet commercially available.
Related terms
- Tamm-Horsfall Protein (Uromodulin)
- The most abundant protein in normal human urine, secreted exclusively by cells of the thick ascending limb of Henle's loop in the...
- Creatinine
- A breakdown product of creatine phosphate in muscle. It is filtered by the kidneys and excreted in urine at relatively constant rates,...
- Cross-Reactivity
- The capacity of an antibody raised against one analyte to bind structurally related compounds. In RIA, cross-reactivity is the main driver of...
- Eccrine Glands
- The primary sweat glands distributed across most body surfaces, producing a watery secretion mainly of water, sodium chloride, and trace amounts of...
- Human Leucocyte Elastase (HLE)
- A serine protease secreted by vaginal epithelial cells and leucocytes. The primary immunological target for forensic identification of vaginal secretions, detected using...
- Lateral-Flow Immunoassay (LFIA)
- A rapid immunological test format using a nitrocellulose membrane strip. An extracted sample migrates by capillary action past antibody-conjugate and capture zones,...
- Matrix Metalloproteinase-10 (MMP-10)
- A zinc-dependent endopeptidase present in menstrual blood but not in peripheral blood. The principal marker used in lateral-flow assays designed to distinguish...
- RSID-Urine
- Rapid Stain Identification of Urine. An immunochromatographic lateral-flow assay that detects Tamm-Horsfall protein in biological extracts, providing a highly specific confirmatory test...
- Urea
- A product of protein catabolism excreted primarily in urine, present at 200 to 400 mmol per litre. Also present at lower concentrations...
Explained in these topics
- Immunological Identification of Vaginal Secretions, Urine, and Other FluidsAn antimicrobial peptide secreted constitutively by eccrine sweat glands. The primary candidate marker for immunological identification of sweat in forensic sa...
- Urine and Sweat IdentificationA small antimicrobial peptide expressed constitutively in eccrine sweat glands and secreted in sweat. Proposed as a candidate sweat marker in research settings...