Human leucocyte elastase (HLE)
Definition
A serine protease secreted by vaginal epithelial cells and leucocytes. The primary immunological target for forensic identification of vaginal secretions, detected using ELISA or LFIA. Distinct from semen elastase and not present at significant levels in other body fluids.
Related terms
- Cross-reactivity
- The capacity of an antibody raised against one analyte to bind structurally related compounds. In RIA, cross-reactivity is the main driver of...
- Dermcidin
- An antimicrobial peptide secreted constitutively by eccrine sweat glands. The primary candidate marker for immunological identification of sweat in forensic samples, though...
- Lateral-flow immunoassay (LFIA)
- A rapid immunological test format using a nitrocellulose membrane strip. An extracted sample migrates by capillary action past antibody-conjugate and capture zones,...
- Matrix metalloproteinase-10 (MMP-10)
- A zinc-dependent endopeptidase present in menstrual blood but not in peripheral blood. The principal marker used in lateral-flow assays designed to distinguish...
- Tamm-Horsfall protein (uromodulin)
- The most abundant protein in normal human urine, secreted exclusively by cells of the thick ascending limb of Henle's loop in the...
Explained in
- Immunological Identification of Vaginal Secretions, Urine, and Other FluidsA serine protease secreted by vaginal epithelial cells and leucocytes. The primary immunological target for forensic identification of vaginal secretions, dete...