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Beta Elimination Rate (Beta)

Definition

The rate at which BAC falls during the post-absorptive phase of alcohol metabolism, expressed as mg/100 mL/hour. Population mean approximately 15 mg/100 mL/h, range 10-25 mg/100 mL/h.

Symbol
Beta (b)
Unit
mg/100 mL/hour
Population mean
Approximately 15 mg/100 mL/h
Typical range
10 to 25 mg/100 mL/h

Common questions

What is beta used for in forensic casework?+

It is the key input for back-calculating BAC at an earlier time, such as the moment of driving, from a measured BAC at a later blood draw.

Why is using a population-average beta risky in an individual case?+

The true rate for one person can fall well outside the 10-25 range depending on chronic drinking history, body composition, and whether absorption is still ongoing, so applying the average alone can produce a materially wrong retrograde estimate.

Related terms

2100:1 Partition Ratio
The conventional blood/breath partition assumption used by breath alcohol analysers worldwide: 2100 mL of venous blood contains the same mass of ethanol...
Blood Alcohol Concentration (BAC)
Mass of ethanol per unit volume of whole blood, expressed as mg per 100 mL (equivalent to mg/dL or mg%), or as...
DB-ALC1 / DB-ALC2
A matched pair of Agilent fused-silica GC columns used for dual-column orthogonal confirmation of blood ethanol. DB-ALC1 uses a polyethylene glycol stationary...
Internal Standard (IS)
A compound chemically near-identical to the analyte, often a deuterated isotopologue (d3-morphine, d5-EDDP, d5-alprazolam, pyrene-d10), spiked into every sample at a known...
NIST SRM 1828
A series of NIST-certified reference material aqueous ethanol standards (0.02 to 0.40 per cent w/v) used to calibrate forensic blood ethanol analytical...
Partition Coefficient (K)
The ratio of analyte concentration in the liquid phase to concentration in the gas phase at equilibrium. For ethanol in blood at...
Sodium Fluoride / Potassium Oxalate (Grey-Top Tube)
The standard blood collection tube for forensic ethanol analysis. Sodium fluoride inhibits microbial fermentation (which would produce artefactual ethanol post-collection); potassium oxalate...
Static Headspace
A sample preparation technique in which a sealed vial is heated until volatile analytes reach thermodynamic equilibrium between the liquid matrix and...
Widmark Factor (Rho / R)
A dimensionless pharmacokinetic constant that represents the distribution of ethanol across body water. Averages approximately 0.68 for adult males and 0.55 for...

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