OPIDN
Definition
Organophosphate-induced delayed polyneuropathy: a distal sensorimotor neuropathy appearing 2 to 3 weeks after exposure to certain OPs (TOCP, leptophos), mediated by neuropathy target esterase inhibition.
- Full name
- Organophosphate-induced delayed polyneuropathy
- Onset
- 2 to 3 weeks after exposure
- Pattern
- Distal sensorimotor neuropathy
- Mechanism
- Neuropathy target esterase inhibition
- Associated agents
- TOCP, leptophos
Common questions
Why does OPIDN appear weeks after exposure rather than immediately?+
It results from a separate mechanism, inhibition and aging of neuropathy target esterase in nerve tissue, distinct from the acute cholinergic toxicity organophosphates cause immediately through acetylcholinesterase inhibition.
How does OPIDN affect the interpretation of a poisoning case investigated weeks later?+
A delayed neuropathy presenting weeks after a documented or suspected organophosphate exposure can be linked back to that earlier event even though acute symptoms may have already resolved, which matters for both clinical and forensic timelines.
Related terms
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