Aging
Definition
The irreversible loss of one alkyl group from the phosphorylated AChE-organophosphate complex, after which oximes can no longer reactivate the enzyme. Aging half-times range from minutes (soman) to many hours (most agricultural OPs).
Related terms
- Acetylcholinesterase (AChE)
- The enzyme that hydrolyses acetylcholine at cholinergic synapses. Inhibition by organophosphates or carbamates causes accumulation of acetylcholine at muscarinic, nicotinic and central...
- Anupam Verma Committee
- An expert committee constituted by the Ministry of Agriculture in 2013 to review 66 pesticides already banned in other countries but still...
- DUMBBELS
- Mnemonic for the muscarinic side of the cholinergic toxidrome: Diarrhoea, Urination, Miosis, Bronchospasm and Bronchorrhoea, Bradycardia, Emesis, Lacrimation, Salivation.
- Intermediate Syndrome
- Proximal muscle and respiratory weakness appearing 24 to 96 hours after acute organophosphate exposure, requiring mechanical ventilation, distinct from the acute cholinergic...
- OPIDN
- Organophosphate-induced delayed polyneuropathy: a distal sensorimotor neuropathy appearing 2 to 3 weeks after exposure to certain OPs (TOCP, leptophos), mediated by neuropathy...
- Phosphine (PH3)
- The toxic gas liberated when aluminium phosphide reacts with water or gastric acid. It inhibits mitochondrial cytochrome c oxidase, generates reactive oxygen...
Explained in
- Pesticide Poisoning: OP, Carbamate, Pyrethroid, Aluminium PhosphideThe irreversible loss of one alkyl group from the phosphorylated AChE-organophosphate complex, after which oximes can no longer reactivate the enzyme. Aging ha...