Intermediate Syndrome
Definition
Proximal muscle and respiratory weakness appearing 24 to 96 hours after acute organophosphate exposure, requiring mechanical ventilation, distinct from the acute cholinergic crisis and from delayed neuropathy.
Related terms
- Acetylcholinesterase (AChE)
- The enzyme that hydrolyses acetylcholine at cholinergic synapses. Inhibition by organophosphates or carbamates causes accumulation of acetylcholine at muscarinic, nicotinic and central...
- Aging
- The irreversible loss of one alkyl group from the phosphorylated AChE-organophosphate complex, after which oximes can no longer reactivate the enzyme. Aging...
- Anupam Verma Committee
- An expert committee constituted by the Ministry of Agriculture in 2013 to review 66 pesticides already banned in other countries but still...
- DUMBBELS
- Mnemonic for the muscarinic side of the cholinergic toxidrome: Diarrhoea, Urination, Miosis, Bronchospasm and Bronchorrhoea, Bradycardia, Emesis, Lacrimation, Salivation.
- OPIDN
- Organophosphate-induced delayed polyneuropathy: a distal sensorimotor neuropathy appearing 2 to 3 weeks after exposure to certain OPs (TOCP, leptophos), mediated by neuropathy...
- Phosphine (PH3)
- The toxic gas liberated when aluminium phosphide reacts with water or gastric acid. It inhibits mitochondrial cytochrome c oxidase, generates reactive oxygen...
Explained in
- Pesticide Poisoning: OP, Carbamate, Pyrethroid, Aluminium PhosphideProximal muscle and respiratory weakness appearing 24 to 96 hours after acute organophosphate exposure, requiring mechanical ventilation, distinct from the acu...