Dextrorotatory (+)
Definition
Rotating the plane of polarisation clockwise (to the right) as seen facing the light source; designated (+) or d-; the d-methamphetamine and natural sucrose are dextrorotatory compounds.
- Field
- Polarimetry, optical rotation
- Rotation direction
- Clockwise, facing the light source
- Symbol
- (+) or d-
- Examples
- d-methamphetamine, natural sucrose
Common questions
Why does knowing a compound is dextrorotatory matter in a drug case?+
Methamphetamine's d- and l- forms are chemically identical in most standard tests but differ sharply in potency and legal significance, since d-methamphetamine is the potent, controlled form typically associated with illicit manufacture, so optical rotation or a chiral separation method is used to distinguish which isomer, or mixture of both, is present.
Can a sample be dextrorotatory and still contain some of the opposite isomer?+
Yes, the measured rotation reflects the net effect of both isomers present, so a sample that is mostly one isomer with a smaller amount of the other will still show a net dextrorotatory or levorotatory reading, which is why a chiral-specific method is used when the exact isomer ratio matters rather than the net rotation alone.
Related terms
- Biot Equation
- The fundamental equation of polarimetry: [α]_T^λ = α / (c × l), relating observed rotation to specific rotation, concentration, and path length;...
- Chirality
- The property of a molecule that cannot be superimposed on its mirror image; a chiral molecule and its mirror image are enantiomers...
- Enantiomeric Excess (Ee)
- A measure of chiral purity: ee (%) = (R - S)/(R + S) x 100, where R and S are the measured...
- Enantiomers
- Two molecules that are non-superimposable mirror images of each other; they have identical physical properties (melting point, boiling point, solubility) except for...
- Invert Sugar
- The equimolar mixture of glucose and fructose produced by hydrolysis (inversion) of sucrose; laevorotatory overall because fructose's negative rotation exceeds glucose's positive...
- Laevorotatory (-)
- Rotating the plane of polarisation anticlockwise (to the left) as seen facing the light source; designated (-) or l-; l-methamphetamine and natural...
- Laurent Half-Shade Polarimeter
- A classical polarimeter design that uses a half-wave plate covering half the aperture to create two adjacent half-fields; the null point (equal...
- OIML R 139
- International Organisation of Legal Metrology Recommendation R 139 (2014) governing metrological requirements for polarimeters used in official testing; specifies maximum permissible error...
- Optical Rotation (α)
- The angle in degrees through which a chiral solution rotates the plane of polarisation of a plane-polarised light beam; measured by rotating...
- Saccharimeter
- A polarimeter calibrated in International Sugar Degrees (°Z) rather than angular degrees; used in the sugar industry for purity determination under the...
- Specific Optical Rotation ([α])
- The standardised optical rotation of a substance at a defined temperature and wavelength, calculated from the Biot equation: [α] = α /...