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Alcohol dehydrogenase (ADH)

The hepatic enzyme (isoforms ADH1A, ADH1B, ADH1C) that catalyses the first oxidation step of both ethanol (to acetaldehyde) and methanol (to formaldehyde) using NAD+ as cofactor. Competitive inhibition of ADH by ethanol or fomepizole is the basis of methanol antidote therapy.

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Anion-gap metabolic acidosisCongener fingerprintingFomepizole (4-methylpyrazole)Formate (formic acid)FSSAI methanol limitHaemodialysis in methanol poisoningLatency periodPyridineVitreous humour

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