Specific Antidote
Definition
An agent that acts on the poison's mechanism, not just on its symptoms. Naloxone for opioids, NAC for paracetamol, methylene blue for methaemoglobinaemia. Activated charcoal and supportive care are not specific antidotes.
Related terms
- Antidote
- A substance that counteracts a poison by competitive receptor block, enzymatic reactivation, chelation, immune binding or substrate replacement. Antidotes are class-specific, not...
- Atropinisation
- The clinical end point of titrated atropine therapy in cholinergic poisoning: drying of pulmonary secretions, clearing of crepitations, heart rate above 80,...
- DUMBBELS
- Mnemonic for the muscarinic side of the cholinergic toxidrome: Diarrhoea, Urination, Miosis, Bronchospasm and Bronchorrhoea, Bradycardia, Emesis, Lacrimation, Salivation.
- Oxime Reactivation
- Restoration of acetylcholinesterase function by pralidoxime (2-PAM) or obidoxime through cleavage of the organophosphate-enzyme bond, effective only before the enzyme is irreversibly...
- Toxidrome
- A reproducible cluster of clinical findings (vital signs, pupil size, skin, bowel and bladder, mental status) that identifies a class of poison...
Explained in
- Signs, Symptoms and Antidotes of Common PoisonsAn agent that acts on the poison's mechanism, not just on its symptoms. Naloxone for opioids, NAC for paracetamol, methylene blue for methaemoglobinaemia. Acti...