Oxime Reactivation
Definition
Restoration of acetylcholinesterase function by pralidoxime (2-PAM) or obidoxime through cleavage of the organophosphate-enzyme bond, effective only before the enzyme is irreversibly aged, broadly within 24 to 36 hours of exposure.
Related terms
- Antidote
- A substance that counteracts a poison by competitive receptor block, enzymatic reactivation, chelation, immune binding or substrate replacement. Antidotes are class-specific, not...
- Atropinisation
- The clinical end point of titrated atropine therapy in cholinergic poisoning: drying of pulmonary secretions, clearing of crepitations, heart rate above 80,...
- DUMBBELS
- Mnemonic for the muscarinic side of the cholinergic toxidrome: Diarrhoea, Urination, Miosis, Bronchospasm and Bronchorrhoea, Bradycardia, Emesis, Lacrimation, Salivation.
- Specific Antidote
- An agent that acts on the poison's mechanism, not just on its symptoms. Naloxone for opioids, NAC for paracetamol, methylene blue for...
- Toxidrome
- A reproducible cluster of clinical findings (vital signs, pupil size, skin, bowel and bladder, mental status) that identifies a class of poison...
Explained in
- Signs, Symptoms and Antidotes of Common PoisonsRestoration of acetylcholinesterase function by pralidoxime (2-PAM) or obidoxime through cleavage of the organophosphate-enzyme bond, effective only before the...