Neurotoxic Envenomation
Definition
Venom-induced paralysis from blockade of the neuromuscular junction. The Indian cobra produces post-synaptic blockade through alpha-neurotoxins binding the acetylcholine receptor. The common krait produces pre-synaptic blockade through beta-bungarotoxin, which is harder to reverse with antivenom once paralysis is established.
Related terms
- 20WBCT
- Twenty minute whole blood clotting test. A few millilitres of fresh venous blood are placed in a clean dry glass tube, left...
- Autonomic Storm
- The biphasic cardiovascular crisis of Indian red scorpion envenomation. An initial cholinergic phase of vomiting, salivation and bradycardia is followed by an...
- The Big Four
- The four Indian snake species responsible for the bulk of medically significant envenomation: Naja naja (Indian cobra), Bungarus caeruleus (common krait), Daboia...
- Venom ELISA
- An enzyme-linked immunosorbent assay in which species-specific anti-venom antibodies are used to detect residual venom antigen in serum, urine, bite-site exudate or...
- VICC
- Venom-induced consumption coagulopathy, the haemotoxic syndrome of Russell's viper and saw-scaled viper bites in which the venom activates coagulation factors, consumes fibrinogen...
Explained in
- Animal and Venomous Poisons: Snakebite, Insect and MarineVenom-induced paralysis from blockade of the neuromuscular junction. The Indian cobra produces post-synaptic blockade through alpha-neurotoxins binding the ace...