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Autonomic Storm

Definition

The biphasic cardiovascular crisis of Indian red scorpion envenomation. An initial cholinergic phase of vomiting, salivation and bradycardia is followed by an adrenergic phase of hypertension, tachycardia, pulmonary oedema and myocarditis. The Bawaskar protocol uses prazosin to block the adrenergic surge.

Cause
Indian red scorpion envenomation
Cholinergic phase
Vomiting, salivation, bradycardia
Adrenergic phase
Hypertension, tachycardia, pulmonary oedema
Treatment
Prazosin, per the Bawaskar protocol

Common questions

Why does treatment specifically target the adrenergic phase rather than the earlier cholinergic phase?+

The adrenergic phase drives the cardiovascular collapse and pulmonary oedema that are the actual causes of death, so prazosin blocks that later surge even though symptoms begin earlier with cholinergic signs.

Could autonomic storm be mistaken for another medical emergency at first presentation?+

Yes, its cardiovascular and pulmonary signs can resemble other causes of acute pulmonary oedema or myocarditis, which is why a documented scorpion sting history is important to the correct diagnosis.

Related terms

20WBCT
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Neurotoxic Envenomation
Venom-induced paralysis from blockade of the neuromuscular junction. The Indian cobra produces post-synaptic blockade through alpha-neurotoxins binding the acetylcholine receptor. The common...
The Big Four
The four Indian snake species responsible for the bulk of medically significant envenomation: Naja naja (Indian cobra), Bungarus caeruleus (common krait), Daboia...
Venom ELISA
An enzyme-linked immunosorbent assay in which species-specific anti-venom antibodies are used to detect residual venom antigen in serum, urine, bite-site exudate or...
VICC
Venom-induced consumption coagulopathy, the haemotoxic syndrome of Russell's viper and saw-scaled viper bites in which the venom activates coagulation factors, consumes fibrinogen...

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