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Multiple reaction monitoring (MRM)

An LC-MS/MS acquisition mode in which the first quadrupole (Q1) selects a precursor ion at a specific m/z, the second (Q2) fragments it with a collision gas, and the third (Q3) monitors one or more specific product ions. MRM is highly specific because both the precursor mass and the fragmentation product are required to match simultaneously.

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Related terms

Category A methodCategory B methodCFSL Hyderabad explosives wingControl swab (background)ENFSI Drugs Working Group (DWG)GC-ECDInternal standard (IS)Ion mobility spectrometry (IMS)ISO/IEC 17025:2017Measurement uncertainty (MU)NDPS small quantity / commercial quantityNIST SRM 8806

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