Mephedrone (4-MMC)
Definition
4-Methylmethcathinone; the dominant first-wave synthetic cathinone, active as a mixed monoamine releaser/reuptake inhibitor. Class B UK since April 2010; Schedule I US since 2011. Used pharmacological mimicry of MDMA, making it popular in UK dance venues 2009-2010.
Related terms
- Alpha-PVP (Alpha-Pyrrolidinopentiophenone)
- The MDPV successor ('flakka') dominant in Florida 2014-2016; associated with excited delirium presentations and multiple fatalities. Identified in over 60 deaths in...
- Cathinone
- The natural beta-ketoamphetamine alkaloid from Catha edulis (khat) plant; the parent scaffold for the synthetic cathinone NPS class. The ketone group at...
- EMCDDA Early Warning System
- The EU mechanism under Council Decision 2005/387/JHA by which national focal points (forensic labs, clinical sites) report new NPS to the EMCDDA...
- Federal Analogue Act (FAA)
- 21 USC 813; a provision of the US Controlled Substances Act declaring substances 'substantially similar' in structure or pharmacology to Schedule I...
- Isotonitazene (ISO)
- A benzimidazole-class novel synthetic opioid (nitazene family) estimated at ~500x the potency of morphine at the mu-opioid receptor. First identified in European...
- MDPV (Methylenedioxypyrovalerone)
- An alpha-pyrrolidinyl cathinone acting primarily as a dopamine/noradrenaline reuptake inhibitor. Central to the US 'bath salts' crisis 2011-2012; substantially more potent and...
- Novel Psychoactive Substance (NPS)
- A substance designed to mimic the effects of a controlled drug while falling outside the definition of any currently scheduled substance; identified...
- Psychoactive Substances Act 2016 (UK)
- UK catch-all legislation prohibiting supply, distribution, import, and export of any substance with psychoactive effects on the CNS, with exemptions for alcohol,...
- Schedule Lag
- The delay between first identification of an NPS in forensic seizures and its formal addition to a controlled substances schedule. In India,...
Explained in
- Novel Psychoactive Substances and the Cathinone Wave4-Methylmethcathinone; the dominant first-wave synthetic cathinone, active as a mixed monoamine releaser/reuptake inhibitor. Class B UK since April 2010; Sched...