Alkaline Fraction
Definition
The organic phase recovered when the aqueous is basified to pH 9 to 10 with ammonium hydroxide or sodium hydroxide and shaken with chloroform-isopropanol or hexane-ethyl acetate. Contains the basic drugs with pKa above 7.5: opioids, tricyclics, SSRIs, antipsychotics, amphetamines, cocaine, LSD, atropine, nicotine and quinine.
Related terms
- Acid Fraction
- The organic phase recovered when the biological aqueous is acidified to pH 2 to 3 and shaken with diethyl ether or chloroform....
- Cut-Off
- The minimum analyte concentration that an SFSL reports as positive. SAMHSA-style serum cut-offs commonly used at Indian labs include morphine 2 ng/mL,...
- DFC
- Drug-facilitated crime, the umbrella term for sexual assault, robbery or kidnapping in which a victim has been incapacitated by a clandestinely administered...
- Neutral Fraction
- The organic phase recovered when the aqueous is buffered to pH 7 to 9 and extracted with a less polar solvent like...
- pKa
- The negative logarithm of the acid dissociation constant. For a basic drug it is the pH at which half the molecules are...
- Post-Mortem Redistribution
- The movement of drugs from solid tissues into central blood after death, due to diffusion along concentration gradients, autolytic enzyme release, and...
Explained in
- Acidic, Neutral and Alkaline Drug AnalysisThe organic phase recovered when the aqueous is basified to pH 9 to 10 with ammonium hydroxide or sodium hydroxide and shaken with chloroform-isopropanol or he...