Selectivity
Definition
The ability of a method to measure the target analyte specifically, even when other substances that might plausibly appear in a real sample are present. Tested by spiking samples with known interferents and confirming the target signal is not distorted.
Related terms
- Limit of detection (LOD)
- The lowest concentration of analyte that produces a signal reliably distinguishable from the instrument noise, conventionally three times the standard deviation of...
- Limit of quantitation (LOQ)
- The lowest concentration at which the assay can produce a quantitative measurement with acceptable precision and accuracy, typically defined as the concentration...
- Repeatability
- The agreement between successive measurements of the same specimen made by the same analyst, on the same instrument, in the same laboratory,...
- Reproducibility
- The closeness of agreement between measurements obtained under changed conditions: different analysts, different instruments, different laboratories, or different times. A wider measure...
- Robustness
- The capacity of a method to remain unaffected by small, deliberate variations in its operating parameters, such as slight changes in temperature,...
Explained in
- Method Validation and Fitness for PurposeThe ability of a method to measure the target analyte specifically, even when other substances that might plausibly appear in a real sample are present. Tested...