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Jet Separator

Definition

Early GC-MS interface (Ryhage, 1964) that used differential pumping through a nozzle to enrich analyte and bleed helium. Replaced by direct capillary coupling once turbomolecular pumps became standard.

Inventor
Ragnar Ryhage
Introduced
1964
Function
Differential-pumping GC-MS interface
Superseded by
Direct capillary coupling with turbomolecular pumps

Common questions

Why did jet separators fall out of use?+

Once turbomolecular pumps made it practical to remove the higher gas load of a capillary column directly, the extra interface added little benefit and introduced some loss of analyte, so direct coupling became standard.

What was the main analytical drawback of a jet separator?+

It tended to discriminate against low molecular weight and more volatile compounds, which could distort quantitation compared with a directly coupled capillary column.

Related terms

Atmospheric Pressure Chemical Ionisation (APCI)
A complementary atmospheric-pressure source that vaporises the LC eluent and uses a corona discharge to ionise a reagent gas, which transfers charge...
Electrospray Ionisation (ESI)
A soft atmospheric-pressure ionisation source that sprays the LC eluent through a charged capillary into a heated counter-current gas, producing protonated or...
Hyphenation
Online coupling of a separation technique (GC, LC, ICP) with a spectrometric detector (MS, FTIR) so identification happens within the same run....
ICP Plasma
Inductively coupled argon plasma at 6,000 to 10,000 K that atomises and ionises samples in ICP-MS, generating singly charged elemental ions for...
Interface
The hardware bridge that transfers analyte from the separation stage to the detector while removing the unwanted mobile phase (carrier gas, solvent,...
Internal Standard / Deuterated Standard
A chemically similar (often perdeuterated) compound spiked into the sample to correct for matrix effects and ionisation suppression. Standard practice in forensic...
Isotope Ratio Mass Spectrometry (IRMS)
Specialised MS that measures precise ratios of light stable isotopes (delta values of 2H, 13C, 15N, 18O, 34S) on a continuous-flow combustion...

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