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Irritant

Definition

A poison that inflames mucous membranes and gut lining without dissolving them outright. Includes inorganic irritants (arsenic, antimony, copper sulphate, phosphorus) and mechanical or chemical irritants of plant origin.

Mechanism
Inflames mucous membranes and gut lining
Inorganic examples
Arsenic, antimony, copper sulphate, phosphorus
Organic examples
Plant-derived mechanical or chemical irritants
Classification level
One category within poisons by mode of action

Common questions

How does an irritant poison differ from a corrosive one?+

A corrosive substance chemically dissolves and destroys tissue on contact, producing severe burns, while an irritant inflames the mucous membrane and gut lining without dissolving them outright, so the tissue damage in irritant poisoning is typically inflammatory rather than destructive.

Why does the origin of an irritant, inorganic versus plant-based, matter to a forensic toxicologist?+

The two groups require different analytical approaches: inorganic irritants like arsenic are detected by elemental techniques such as AAS or ICP-MS, while plant-derived irritants require organic extraction and chromatographic methods, so identifying the likely origin narrows which tests to run.

Related terms

Asphyxiant
A poison that interferes with oxygen delivery or use. Simple asphyxiants (CO2, methane) displace oxygen; chemical asphyxiants (CO, HCN, H2S) block haemoglobin...
Corrosive
A poison that destroys tissue at the point of contact by acid, alkali or oxidising action. Concentrated H2SO4, HCl, HNO3 and NaOH...
Manner of Poisoning
The medico-legal label for how the poison reached the victim: accidental, suicidal or homicidal. Decided by the IO and the magistrate, not...
Neurotoxic
A poison whose primary target is nervous tissue. Subdivided by site of action into cerebral (alcohol, opioids), spinal (strychnine, gelsemium) and peripheral...
Poison
Paracelsus framed the working definition in 1538 as 'sola dosis facit venenum', the dose alone makes the poison. Any substance, including water...

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