Dialysis
Definition
Separation of small molecules from large ones across a semipermeable cellulose membrane. In forensic toxicology, used for clean-up of blood and plasma before HPLC, LC-MS/MS or AAS.
Related terms
- Conway Microdiffusion Cell
- A two-compartment glass or ceramic dish with a central well and an outer ring, sealed at the rim. The poison is released...
- Equilibrium Dialysis
- Variant in which the drug is allowed to redistribute across the membrane until the unbound concentration on both sides is equal. The...
- MWCO
- Molecular weight cut-off, the nominal size above which the membrane retains solutes. Forensic dialysis tubing typically uses 12 to 14 kDa MWCO,...
- Simple Distillation
- Heating an aqueous sample in a round-bottom flask and collecting the condensed vapour. Used for volatiles that boil below 100 degrees C...
- Steam Distillation
- Passing live steam through a sample so that volatile organic compounds co-distil with water at a temperature below their own boiling point....
Explained in
- Distillation, Microdiffusion and Dialysis TechniquesSeparation of small molecules from large ones across a semipermeable cellulose membrane. In forensic toxicology, used for clean-up of blood and plasma before H...