Coagulative Necrosis
Definition
Cell death in which the architecture of the tissue is preserved as a firm, pale eschar because the denaturing agent precipitates proteins in situ. Produced by strong acids. The self-limiting protein-precipitate barrier reduces depth of penetration at equivalent exposures compared with alkali.
Related terms
- Centrolobular Necrosis
- Hepatocellular necrosis in zone 3 of the hepatic acinus, the zone most vulnerable to ischaemia due to lowest oxygen tension and highest...
- Liquefactive Necrosis
- Cell death in which the normal tissue architecture is dissolved into a soft, liquid mass. Produced by strong alkalis (hydroxide saponifies lipids...
- Paradoxical Undressing
- Removal of clothing in the final phase of hypothermia, driven by central thermoregulatory failure and peripheral vasodilatation producing a subjective sensation of...
- Paraquat Lung Score
- Radiological scoring system combining chest X-ray infiltrate extent and CT parenchymal changes to predict 30-day mortality in paraquat poisoning. Developed at the...
- Wischnewski Spots
- Small, haemorrhagic, oval erosions at the tips of the gastric rugal folds. The most specific autopsy finding in hypothermia, present in 56-85%...
Explained in
- Chemical Burns, Hypothermia and HyperthermiaCell death in which the architecture of the tissue is preserved as a firm, pale eschar because the denaturing agent precipitates proteins in situ. Produced by...