Cell-Free DNA
Definition
DNA outside intact cells, including fragments in plasma. Collection and processing can change the proportions represented in an extract. The presence of cell-free DNA does not by itself identify a tissue or transfer route.
- Context
- Biological material
For example, a plasma preparation can contain extracellular DNA fragments even when intact nucleated cells have largely been removed from the tested portion.
A suitable assay and interpretation are still required.
Related terms
- Donor Proposition
- A stated explanation about whose DNA contributed, distinct from how it arrived. A contributor proposition concerns whose genetic material is represented. It...
- Leukocyte
- A leukocyte is a white blood cell involved in immune functions and ordinarily containing a nucleus in humans. Leukocytes can contribute nuclear...
- Plasma
- The liquid fraction of blood (approximately 55% by volume), containing water, proteins (albumin, immunoglobulins, fibrinogen, clotting factors), electrolytes, glucose, hormones, and dissolved...
- Presumptive Blood Test
- A screening reaction compatible with blood but subject to alternative causes. Substrates and other catalysts can also affect the response. A positive...