Arsenic (As)
Metalloid; trivalent arsenite (As III) is 60 times more toxic than pentavalent arsenate (As V). Thiol-group blocker that poisons mitochondrial enzymes (pyruvate dehydrogenase). Sources: contaminated groundwater (West Bengal arsenicosis belt), Paris green pesticide, opium adulteration, traditional Ayurvedic and Unani preparations.