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Extraction

The first step in sample preparation. The analyte is pulled out of its original matrix (blood, urine, viscera, soil, paint chip) into a solvent or sorbent that the instrument can handle. Choices range from classical liquid-liquid extraction to solid-phase extraction (SPE), solid-phase microextraction (SPME), accelerated solvent extraction (ASE), Soxhlet for fats and lipids, and dilute-and-shoot for high-concentration urine work.

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Related terms

Bracketing standardsCalibration curveCertified reference material (CRM)Internal standard (IS)Limit of detection (LOD) and limit of quantitation (LOQ)Recovery

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