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CID and HCD

Collision-induced dissociation. The precursor is accelerated and collides with a neutral gas (nitrogen, argon, helium) in the collision cell. Internal energy converts to bond-cleavage. Higher-energy collisional dissociation (HCD) on Orbitrap instruments uses a dedicated cell at higher energy and gives more reproducible fragmentation than ion-trap CID.

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Related terms

Accurate mass and mass defectDeuterated internal standardMRM (multiple reaction monitoring)Quantifier and qualifier transitionsTandem MS (MS/MS)

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