ABO transferase
Definition
A glycosyltransferase enzyme encoded by the ABO gene on chromosome 9. The A allele encodes an enzyme that adds N-acetylgalactosamine to H antigen, creating A antigen. The B allele encodes an enzyme that adds galactose, creating B antigen. The O allele encodes a non-functional form.
Related terms
- Bombay phenotype (Oh)
- A rare phenotype in which individuals lack functional H antigen on red cells and in secretions due to mutations in FUT1 (and...
- Forward grouping (cell grouping)
- The direct test of red blood cells with known anti-A and anti-B reagent antibodies to determine which ABO antigens are present on...
- H antigen
- A fucose-containing oligosaccharide on red cell surfaces and secreted epithelial cells, produced by FUT1 (on red cells) and FUT2 (in secretions). It...
- Reverse grouping (serum grouping)
- Testing a person's serum against known A1 and B reagent red cells to identify which antibodies are present. A healthy adult with...
- Secretor status
- A genetic trait that determines whether a person expresses their ABO blood group antigens in secreted body fluids such as saliva, semen,...
Explained in
- The ABO Blood Group System: Genetics and SerologyA glycosyltransferase enzyme encoded by the ABO gene on chromosome 9. The A allele encodes an enzyme that adds N-acetylgalactosamine to H antigen, creating A a...