CDE nomenclature (Fisher-Race)
Definition
The modern standard notation for Rh antigens, naming three antithetical pairs: C/c, D (no d), and E/e. Haplotypes such as CDe (R1), cDE (R2), and cde (r) describe the combination of alleles on one chromosome. The notation aligns directly with the RHD and RHCE gene structure.
Related terms
- D antigen
- The most immunogenic Rh antigen, encoded by the RHD gene. Its presence defines Rh-positive; its absence defines Rh-negative. No naturally occurring anti-D...
- Indirect antiglobulin test (IAT)
- A two-stage serological test in which IgG antibody is incubated with red cells, unbound antibody is washed away, and anti-human globulin (Coombs...
- Rh-Hr nomenclature (Wiener)
- An earlier notation system using alphanumeric agglutinogen codes (R0, R1, R2, Rz, r, r', r'', ry) for Rh haplotypes. Wiener's R1 corresponds...
- RHD genotyping
- PCR-based molecular typing of the RHD gene to determine D antigen status from DNA, including from dried biological evidence where serological red...
- Weak D (formerly Du)
- A reduced-expression variant of the D antigen that does not agglutinate red cells with standard IgM anti-D reagent in the direct test...
Explained in
- The Rh Blood Group System in Forensic ContextThe modern standard notation for Rh antigens, naming three antithetical pairs: C/c, D (no d), and E/e. Haplotypes such as CDe (R1), cDE (R2), and cde (r) descr...