Prostate-specific antigen (PSA / p30)
Definition
A 33-kDa serine protease encoded by the KLK3 gene, secreted by prostate epithelial cells into seminal plasma at 0.5-2 mg/mL. Detected in forensic stain extracts to confirm semen. Previously known as p30 in the serological literature.
Related terms
- ABAcard p30 (HemaTrace p30)
- A lateral-flow immunochromatographic card that detects PSA at approximately 0.2-4 ng/mL of extract. Widely used in sexual assault kit triage because it...
- RSID-Semen
- Rapid Stain Identification of Semen: an immunochromatographic lateral-flow strip from Independent Forensics that detects semenogelin I and II with sensitivity to approximately...
- Semenogelin I and II
- High-molecular-weight proteins secreted by the seminal vesicles that form the semen coagulum immediately after ejaculation. PSA then cleaves them to liquefy the...
- Sensitivity and specificity in forensic context
- Sensitivity is the probability of a positive result when semen is truly present; specificity is the probability of a negative result when...
- Seratec PSA Semiquant
- A lateral-flow PSA strip with a semi-quantitative band-intensity scale. Line intensity corresponds approximately to 1 ng/mL, 2 ng/mL, or greater concentrations, useful...
Explained in
- p30/PSA and RSID-SemenA 33-kDa serine protease encoded by the KLK3 gene, secreted by prostate epithelial cells into seminal plasma at 0.5-2 mg/mL. Detected in forensic stain extract...