Frameshift mutation
Definition
A change in the reading frame of a coding sequence caused by an insertion or deletion of a number of nucleotides that is not a multiple of three. All codons downstream of the change are altered, usually producing a truncated or non-functional protein.
Related terms
- DNA polymerase
- The enzyme that synthesises new DNA by adding deoxyribonucleoside triphosphates complementary to the template strand. In humans, polymerase delta copies the lagging...
- Okazaki fragment
- A short segment of DNA (100 to 200 nucleotides in eukaryotes) synthesised on the lagging template strand in the 5-prime to 3-prime...
- Point mutation
- A change in a single nucleotide in the DNA sequence. A transition substitutes one purine for another or one pyrimidine for another...
- Semi-conservative replication
- The mode of DNA copying in which each daughter double helix retains one parental strand and acquires one newly synthesised strand, confirmed...
- Short tandem repeat (STR) slippage
- Replication slippage at a repetitive locus where the template and nascent strands temporarily misalign. If the nascent strand slips forward, one repeat...
Explained in
- DNA Replication and MutationA change in the reading frame of a coding sequence caused by an insertion or deletion of a number of nucleotides that is not a multiple of three. All codons do...